Reverse Engineering the Cooperative Machinery of Human Hemoglobin

Reverse Engineering the Cooperative Machinery of Human Hemoglobin

Hemoglobin transports molecular oxygen from the lungs to all human tissues for cellular respiration. Its α2β2 tetrameric assembly undergoes cooperative binding and releasing of oxygen for superior efficiency and responsiveness. Over past decades, hundreds of hemoglobin structures were determined under a wide range of conditions for investigation of molecular mechanism of cooperativity. Based on...

Reverse engineering the human brain

Advances in the physical sciences often foster advances in the biological sciences. In this paper I deal with just one of those many contributions and describe a trail that leads from Faraday’s discovery of electromagnetic induction to a technique called transcranial magnetic stimulation (TMS), which can be used to temporarily prevent the brain from carrying out some of its normal functions. Th...

CCE Case Study - Heavy Machinery Design and Reverse Engineering

A quantitative model for the cooperative mechanism of human hemoglobin.

A quantitative model has been developed for the cooperative oxygenation of human hemoglobin. The model correlates the structural and energetic features of ligand-linked subunit interactions within the tetrameric molecule and the coupling of these interactions to the binding of oxygen and Bohr protons. Recent findings are incorporated regarding (i) the sites of regulatory energy change within th...

the effects of integrating cooperative learning into vocabulary learning of elementary school students

the purpose of the research is to examine if integrating cooperative learning into vocabulary learning helps to increase word recognition of students in an elementary school in iran. it tries to investigate whether cooperative learning approach enables students to improve their language learning. this research used stad (students team achievement division) as a cooperative model in this study. ...